Different methods for hepatic flow measurements: a narrative review

Abstract

Hepatic blood flow measurement constitutes an essential tool for successful hepatic surgery, especially in situations where graft patency needs to be controlled, such as for instance during and after liver transplantation. In addition, because of its complex intrinsic regulation, the hepatic circulation may be seriously affected in the perioperative setting not only because of systemic hemodynamic alterations but also secondary to the administration of various drugs including anesthetic agents. Unravelling and understanding such effects implies studies involving measurement of hepatic blood flow. Therefore, knowledge and understanding of various tools for estimation of hepatic blood flow is important for correct interpretation of findings from experimental and clinical studies before potential implementation in daily clinical practice. This review summarizes the different techniques, their strengths and limitations, and potential applications in clinical practice and research.